Hyperpigmentation of lips (Lip Darkening) Can be associated with a variety of conditions like smoking, B12 deficiency. Inflammation Disorders, hormonal disorders, Drugs, Cosmetic products, Aging Etc... This Darkened lips can be treated with creams, chemical peels, and lasers. Laser treatment with Q- Switched Nd Yag laser is highly efficient. For healthy, beautiful lips visit Cleo.